| Segment | Player | Tms | 1st Yr | L Yr | YrsCount | G | IP | BF | W | L | BF/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Lg | LACKEY,John | BB, EID, HCS, HOO, LS, MMW | 2005 | 2017 | 11 | 350 | 2284.2 | 9744 | 122 | 130 | 38.4 |
| Lg | LESTER,Jon | HOO, MEN, NAP, SAT | 2006 | 2021 | 16 | 395 | 2430.0 | 10198 | 167 | 128 | 37.8 |
| Lg | HAREN,Dan | ARC, MBS | 2005 | 2015 | 11 | 388 | 2450.1 | 10289 | 146 | 140 | 37.8 |
| Lg | SABATHIA,C.C. | ARC, BE | 2005 | 2018 | 14 | 406 | 2708.1 | 11332 | 159 | 150 | 37.7 |
| Lg | VERLANDER,Justin | NAP | 2006 | 2019 | 14 | 415 | 2735.1 | 11347 | 207 | 114 | 37.3 |
| Lg | HERNANDEZ,Felix | HOO, MEN, OMR, SAT, WAS | 2005 | 2018 | 14 | 376 | 2610.2 | 10792 | 164 | 128 | 37.2 |
| Lg | WAINWRIGHT,Adam | CNH, HOO, HTA, HUM, SES | 2005 | 2021 | 15 | 415 | 2229.2 | 9132 | 134 | 110 | 36.9 |
| Lg | GREINKE,Zack | BB, HOO, NAP, NJH, SFS | 2005 | 2021 | 16 | 523 | 3197.2 | 13072 | 228 | 124 | 36.8 |
| Lg | HAMELS,Cole | HOO, LAA, SES | 2006 | 2019 | 14 | 402 | 2557.2 | 10420 | 184 | 97 | 36.7 |
| Lg | BUMGARNER,Madison | HOO, HTA, SS, SYR | 2009 | 2021 | 13 | 346 | 2161.2 | 8815 | 143 | 106 | 36.7 |
| Lg | SCHERZER,Max | OMR, SES | 2008 | 2021 | 14 | 391 | 2602.0 | 10585 | 181 | 115 | 36.6 |
| Lg | PRICE,David | HUM | 2008 | 2021 | 13 | 340 | 2140.1 | 8678 | 142 | 99 | 36.5 |
| Lg | KERSHAW,Clayton | HTA, HUM, SYR | 2008 | 2021 | 14 | 390 | 2787.2 | 11058 | 211 | 102 | 35.7 |