| Lg | KERSHAW,Clayton | HTA, HUM, SYR | 2008 | 2021 | 14 | 390 | 387 | 82 | 2787.2 | 5.9 |
| Lg | HERNANDEZ,Felix | HOO, MEN, OMR, SAT, WAS | 2005 | 2018 | 14 | 376 | 373 | 70 | 2610.2 | 5.0 |
| Lg | HAREN,Dan | ARC, MBS | 2005 | 2015 | 11 | 388 | 368 | 66 | 2450.1 | 6.0 |
| Lg | VERLANDER,Justin | NAP | 2006 | 2019 | 14 | 415 | 389 | 66 | 2735.1 | 4.7 |
| Lg | GREINKE,Zack | BB, HOO, NAP, NJH, SFS | 2005 | 2021 | 16 | 523 | 458 | 65 | 3197.2 | 4.1 |
| Lg | SCHERZER,Max | OMR, SES | 2008 | 2021 | 14 | 391 | 374 | 63 | 2602.0 | 4.5 |
| Lg | SABATHIA,C.C. | ARC, BE | 2005 | 2018 | 14 | 406 | 401 | 61 | 2708.1 | 4.4 |
| Lg | BUMGARNER,Madison | HOO, HTA, SS, SYR | 2009 | 2021 | 13 | 346 | 306 | 54 | 2161.2 | 4.2 |
| Lg | SHIELDS,James | AAE, LS, POT | 2006 | 2017 | 11 | 292 | 282 | 53 | 2022.1 | 4.8 |
| Lg | HALLADAY,Roy | MEN, SAT | 2005 | 2012 | 8 | 241 | 237 | 53 | 1712.2 | 6.6 |
| Lg | LACKEY,John | BB, EID, HCS, HOO, LS, MMW | 2005 | 2017 | 11 | 350 | 345 | 48 | 2284.2 | 4.4 |
| Lg | LEE,Cliff | COB, CRC, HOO, LS | 2005 | 2014 | 10 | 284 | 261 | 47 | 1911.1 | 4.7 |
| Lg | ARROYO,Bronson | ABB, BA, HCS | 2005 | 2013 | 8 | 258 | 257 | 45 | 1727.2 | 5.6 |
| Lg | LOHSE,Kyle | AS, BOO, CNH, COB, CRC, CSK | 2005 | 2016 | 12 | 314 | 303 | 41 | 2033.2 | 3.4 |
| Lg | LESTER,Jon | HOO, MEN, NAP, SAT | 2006 | 2021 | 16 | 395 | 342 | 41 | 2430.0 | 2.6 |
| Lg | QUINTANA,Jose | BE, JBE, MBS, PVP, SAM, TZD | 2012 | 2021 | 10 | 297 | 268 | 39 | 1819.1 | 3.9 |
| Lg | HUDSON,Tim | BAL, GBD, LS | 2005 | 2015 | 11 | 300 | 270 | 39 | 1885.2 | 3.5 |
| Lg | OSWALT,Roy | HOO, LS | 2005 | 2011 | 7 | 217 | 212 | 38 | 1515.0 | 5.4 |
| Lg | WILLIS,Dontrelle | SEA | 2005 | 2011 | 5 | 116 | 99 | 37 | 747.2 | 7.4 |
| Lg | LILLY,Ted | CHH, GBH, SP6, WAS | 2005 | 2012 | 8 | 217 | 214 | 37 | 1413.1 | 4.6 |
| Lg | VAZQUEZ,Javier | CRS, GBH, OMR, TPT | 2005 | 2011 | 7 | 214 | 207 | 37 | 1375.1 | 5.3 |
| Lg | SANTANA,Ervin | BB, NJH, SES, SP6 | 2005 | 2017 | 12 | 321 | 312 | 36 | 2044.0 | 3.0 |
| Lg | CUETO,Johnny | HOO, MEN, SAT, WAS | 2008 | 2021 | 14 | 274 | 265 | 36 | 1765.1 | 2.6 |
| Lg | GONZALEZ,Gio | COB, SYR | 2009 | 2019 | 11 | 356 | 261 | 34 | 1885.0 | 3.1 |
| Lg | SALE,Chris | BA | 2011 | 2021 | 10 | 268 | 194 | 33 | 1451.1 | 3.3 |
| Lg | WEAVER,Jered | CSK, HOO, NAP | 2006 | 2016 | 11 | 319 | 295 | 33 | 1995.2 | 3.0 |