| Segment | Player | Tms | 1st Yr | L Yr | YrsCount | G | IP | SO | W | L | SO/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Lg | SCHERZER,Max | OMR, SES | 2008 | 2021 | 14 | 391 | 2602.0 | 2951 | 181 | 115 | 10.2 |
| Lg | KERSHAW,Clayton | HTA, HUM, SYR | 2008 | 2021 | 14 | 390 | 2787.2 | 3020 | 211 | 102 | 9.8 |
| Lg | VERLANDER,Justin | NAP | 2006 | 2019 | 14 | 415 | 2735.1 | 2822 | 207 | 114 | 9.3 |
| Lg | PRICE,David | HUM | 2008 | 2021 | 13 | 340 | 2140.1 | 2140 | 142 | 99 | 9.0 |
| Lg | HAMELS,Cole | HOO, LAA, SES | 2006 | 2019 | 14 | 402 | 2557.2 | 2533 | 184 | 97 | 8.9 |
| Lg | SABATHIA,C.C. | ARC, BE | 2005 | 2018 | 14 | 406 | 2708.1 | 2657 | 159 | 150 | 8.8 |
| Lg | HERNANDEZ,Felix | HOO, MEN, OMR, SAT, WAS | 2005 | 2018 | 14 | 376 | 2610.2 | 2512 | 164 | 128 | 8.7 |
| Lg | BUMGARNER,Madison | HOO, HTA, SS, SYR | 2009 | 2021 | 13 | 346 | 2161.2 | 2094 | 143 | 106 | 8.7 |
| Lg | GREINKE,Zack | BB, HOO, NAP, NJH, SFS | 2005 | 2021 | 16 | 523 | 3197.2 | 3046 | 228 | 124 | 8.6 |
| Lg | HAREN,Dan | ARC, MBS | 2005 | 2015 | 11 | 388 | 2450.1 | 2288 | 146 | 140 | 8.4 |
| Lg | LESTER,Jon | HOO, MEN, NAP, SAT | 2006 | 2021 | 16 | 395 | 2430.0 | 2189 | 167 | 128 | 8.1 |
| Lg | LACKEY,John | BB, EID, HCS, HOO, LS, MMW | 2005 | 2017 | 11 | 350 | 2284.2 | 1961 | 122 | 130 | 7.7 |
| Lg | WAINWRIGHT,Adam | CNH, HOO, HTA, HUM, SES | 2005 | 2021 | 15 | 415 | 2229.2 | 1871 | 134 | 110 | 7.6 |