| Segment | Player | Tms | 1st Yr | L Yr | YrsCount | G | IP | BB | W | L | BB/9 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Lg | HAREN,Dan | ARC, MBS | 2005 | 2015 | 11 | 388 | 2450.1 | 627 | 146 | 140 | 2.30 |
| Lg | PRICE,David | HUM | 2008 | 2021 | 13 | 340 | 2140.1 | 549 | 142 | 99 | 2.31 |
| Lg | BUMGARNER,Madison | HOO, HTA, SS, SYR | 2009 | 2021 | 13 | 346 | 2161.2 | 568 | 143 | 106 | 2.36 |
| Lg | SCHERZER,Max | OMR, SES | 2008 | 2021 | 14 | 391 | 2602.0 | 712 | 181 | 115 | 2.46 |
| Lg | HAMELS,Cole | HOO, LAA, SES | 2006 | 2019 | 14 | 402 | 2557.2 | 704 | 184 | 97 | 2.48 |
| Lg | GREINKE,Zack | BB, HOO, NAP, NJH, SFS | 2005 | 2021 | 16 | 523 | 3197.2 | 896 | 228 | 124 | 2.52 |
| Lg | KERSHAW,Clayton | HTA, HUM, SYR | 2008 | 2021 | 14 | 390 | 2787.2 | 806 | 211 | 102 | 2.60 |
| Lg | WAINWRIGHT,Adam | CNH, HOO, HTA, HUM, SES | 2005 | 2021 | 15 | 415 | 2229.2 | 651 | 134 | 110 | 2.63 |
| Lg | LACKEY,John | BB, EID, HCS, HOO, LS, MMW | 2005 | 2017 | 11 | 350 | 2284.2 | 678 | 122 | 130 | 2.67 |
| Lg | SABATHIA,C.C. | ARC, BE | 2005 | 2018 | 14 | 406 | 2708.1 | 816 | 159 | 150 | 2.71 |
| Lg | VERLANDER,Justin | NAP | 2006 | 2019 | 14 | 415 | 2735.1 | 827 | 207 | 114 | 2.72 |
| Lg | HERNANDEZ,Felix | HOO, MEN, OMR, SAT, WAS | 2005 | 2018 | 14 | 376 | 2610.2 | 866 | 164 | 128 | 2.99 |
| Lg | LESTER,Jon | HOO, MEN, NAP, SAT | 2006 | 2021 | 16 | 395 | 2430.0 | 843 | 167 | 128 | 3.12 |