| Segment | Player | Tms | 1st Yr | L Yr | YrsCount | G | IP | Ops | Sves | Hld | Blwn |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Lg | CORDERO,Francisco | ALM, AS, BOO, CRC, HOO | 2005 | 2011 | 7 | 425 | 467.1 | 161 | 89 | 37 | 35 |
| Lg | RODRIGUEZ,Francisco | ARC, LAA, OMR | 2005 | 2016 | 11 | 569 | 708.1 | 230 | 147 | 42 | 35 |
| Lg | JANSEN,Kenley | BA, WAS | 2010 | 2021 | 12 | 579 | 685.2 | 209 | 117 | 57 | 33 |
| Lg | PAPELBON,Jonathan | LS, MEN, SAT | 2005 | 2016 | 12 | 535 | 643.2 | 224 | 96 | 95 | 32 |
| Lg | FUENTES,Brian | GBH, HWS, RAR, SS | 2005 | 2011 | 7 | 371 | 385.2 | 160 | 84 | 40 | 32 |
| Lg | O'DAY,Darren | MBS | 2008 | 2020 | 12 | 469 | 661.2 | 200 | 120 | 51 | 29 |
| Lg | CHAPMAN,Aroldis | NAP | 2010 | 2021 | 12 | 465 | 533.0 | 241 | 144 | 65 | 29 |
| Lg | CISHEK,Steve | HVL, MBS | 2011 | 2021 | 10 | 454 | 606.2 | 190 | 100 | 58 | 29 |
| Lg | ROBERTSON,David | ABB, BA, BB, SES | 2008 | 2018 | 11 | 486 | 592.0 | 171 | 88 | 52 | 28 |
| Lg | VALVERDE,Jose | SYR | 2005 | 2011 | 7 | 390 | 445.0 | 117 | 35 | 54 | 27 |
| Lg | KINTZLER,Brandon | CSK, JBE, MBS, PVP, SAM, SYR, TZD | 2011 | 2021 | 11 | 320 | 446.2 | 105 | 15 | 64 | 27 |
| Lg | ALVAREZ,Jose | BB, CRS, HOO, OMR | 2015 | 2021 | 7 | 343 | 385.0 | 102 | 29 | 46 | 26 |
| Lg | TREINEN,Blake | BE, CSK, LS | 2014 | 2021 | 8 | 446 | 552.2 | 164 | 80 | 54 | 26 |
| Lg | MADSON,Ryan | CRC, HOO, NAP, SEA | 2005 | 2018 | 11 | 612 | 791.2 | 191 | 83 | 81 | 26 |
| Lg | BROXTON,Jonathan | COB, CRC, MM, OMR, TPT | 2005 | 2015 | 10 | 471 | 590.1 | 145 | 42 | 76 | 26 |
| Lg | RIVERA,Mariano | AAE, POT, SES, WAS | 2005 | 2013 | 9 | 494 | 561.1 | 241 | 167 | 46 | 25 |
| Lg | HERRERA,Kelvin | BE, LS, SAT | 2012 | 2018 | 6 | 349 | 426.1 | 136 | 44 | 67 | 25 |
| Lg | SORIA,Joakim | BEG, CHH, OMR, SS | 2007 | 2020 | 12 | 519 | 656.1 | 172 | 82 | 62 | 25 |
| Lg | FAMILIA,Jeurys | HUM | 2014 | 2021 | 8 | 359 | 405.1 | 108 | 35 | 48 | 25 |
| Lg | RODNEY,Fernando | BEG, CHH, GBH, SS | 2005 | 2018 | 14 | 566 | 628.2 | 194 | 113 | 57 | 24 |
| Lg | SMITH,Joe | ARC, CNH, LS, OMR | 2007 | 2019 | 12 | 562 | 662.0 | 135 | 65 | 43 | 24 |
| Lg | HAND,Brad | BEG, SS | 2015 | 2021 | 7 | 351 | 401.0 | 129 | 62 | 42 | 24 |
| Lg | DAVIS,Wade | COB, CRC, OMR | 2009 | 2018 | 9 | 383 | 710.2 | 194 | 160 | 10 | 24 |
| Lg | MILLER,Andrew | COB, HOO, NAP, OMR | 2006 | 2020 | 11 | 352 | 466.0 | 158 | 91 | 43 | 24 |
| Lg | WATSON,Tony | WAS | 2013 | 2021 | 9 | 506 | 507.2 | 180 | 56 | 96 | 24 |
| Lg | ZIEGLER,Brad | ARC, HOO | 2008 | 2016 | 9 | 519 | 612.1 | 189 | 59 | 109 | 24 |