| Segment | Player | Tms | 1st Yr | L Yr | YrsCount | GS | QS | W | L | PCT | IP | QS/GS | QS / Yr |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lg | GREINKE,Zack | BB, HOO, NAP, NJH, SFS | 2005 | 2021 | 16 | 458 | 263 | 228 | 124 | .648 | 3197.2 | .574 | 16.4 |
| Lg | KERSHAW,Clayton | HTA, HUM, SYR | 2008 | 2021 | 14 | 387 | 260 | 211 | 102 | .674 | 2787.2 | .672 | 18.6 |
| Lg | HAMELS,Cole | HOO, LAA, SES | 2006 | 2019 | 14 | 389 | 251 | 184 | 97 | .655 | 2557.2 | .645 | 17.9 |
| Lg | SCHERZER,Max | OMR, SES | 2008 | 2021 | 14 | 374 | 240 | 181 | 115 | .611 | 2602.0 | .642 | 17.1 |
| Lg | SABATHIA,C.C. | ARC, BE | 2005 | 2018 | 14 | 401 | 231 | 159 | 150 | .515 | 2708.1 | .576 | 16.5 |
| Lg | HERNANDEZ,Felix | HOO, MEN, OMR, SAT, WAS | 2005 | 2018 | 14 | 373 | 223 | 164 | 128 | .562 | 2610.2 | .598 | 15.9 |
| Lg | VERLANDER,Justin | NAP | 2006 | 2019 | 14 | 389 | 216 | 207 | 114 | .645 | 2735.1 | .555 | 15.4 |
| Lg | PRICE,David | HUM | 2008 | 2021 | 13 | 314 | 208 | 142 | 99 | .589 | 2140.1 | .662 | 16.0 |
| Lg | WAINWRIGHT,Adam | CNH, HOO, HTA, HUM, SES | 2005 | 2021 | 15 | 321 | 197 | 134 | 110 | .549 | 2229.2 | .614 | 13.1 |
| Lg | BUMGARNER,Madison | HOO, HTA, SS, SYR | 2009 | 2021 | 13 | 306 | 196 | 143 | 106 | .574 | 2161.2 | .641 | 15.1 |
| Lg | LESTER,Jon | HOO, MEN, NAP, SAT | 2006 | 2021 | 16 | 342 | 195 | 167 | 128 | .566 | 2430.0 | .570 | 12.2 |
| Lg | HAREN,Dan | ARC, MBS | 2005 | 2015 | 11 | 368 | 180 | 146 | 140 | .510 | 2450.1 | .489 | 16.4 |
| Lg | LACKEY,John | BB, EID, HCS, HOO, LS, MMW | 2005 | 2017 | 11 | 345 | 174 | 122 | 130 | .484 | 2284.2 | .504 | 15.8 |
| Lg | LEE,Cliff | COB, CRC, HOO, LS | 2005 | 2014 | 10 | 261 | 173 | 137 | 71 | .659 | 1911.1 | .663 | 17.3 |
| Lg | LOHSE,Kyle | AS, BOO, CNH, COB, CRC, CSK | 2005 | 2016 | 12 | 303 | 172 | 128 | 126 | .504 | 2033.2 | .568 | 14.3 |
| Lg | LYNN,Lance | CRS, HOO, WAS | 2011 | 2021 | 10 | 275 | 169 | 133 | 79 | .627 | 1854.0 | .615 | 16.9 |
| Lg | BUEHRLE,Mark | HUM, LAA | 2005 | 2015 | 11 | 290 | 167 | 106 | 116 | .477 | 1921.0 | .576 | 15.2 |
| Lg | SHIELDS,James | AAE, LS, POT | 2006 | 2017 | 11 | 282 | 164 | 134 | 93 | .590 | 2022.1 | .582 | 14.9 |
| Lg | HUDSON,Tim | BAL, GBD, LS | 2005 | 2015 | 11 | 270 | 163 | 136 | 84 | .618 | 1885.2 | .604 | 14.8 |
| Lg | WEAVER,Jered | CSK, HOO, NAP | 2006 | 2016 | 11 | 295 | 163 | 146 | 91 | .616 | 1995.2 | .553 | 14.8 |
| Lg | CUETO,Johnny | HOO, MEN, SAT, WAS | 2008 | 2021 | 14 | 265 | 159 | 122 | 85 | .589 | 1765.1 | .600 | 11.4 |
| Lg | SANTANA,Ervin | BB, NJH, SES, SP6 | 2005 | 2017 | 12 | 312 | 154 | 113 | 135 | .456 | 2044.0 | .494 | 12.8 |
| Lg | HALLADAY,Roy | MEN, SAT | 2005 | 2012 | 8 | 237 | 151 | 126 | 72 | .636 | 1712.2 | .637 | 18.9 |
| Lg | GONZALEZ,Gio | COB, SYR | 2009 | 2019 | 11 | 261 | 149 | 119 | 98 | .548 | 1885.0 | .571 | 13.5 |
| Lg | COLE,Gerrit | BB, SFS | 2013 | 2021 | 9 | 236 | 148 | 106 | 66 | .616 | 1558.2 | .627 | 16.4 |