| Segment | Player | Tms | 1st Yr | L Yr | YrsCount | G | GS | CG | W | L | PCT | IP | SHO | Sh/Yr |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lg | BUMGARNER,Madison | HOO, HTA, SS, SYR | 2009 | 2021 | 13 | 346 | 306 | 54 | 143 | 106 | .574 | 2161.2 | 31 | 2.4 |
| Lg | HERNANDEZ,Felix | HOO, MEN, OMR, SAT, WAS | 2005 | 2018 | 14 | 376 | 373 | 70 | 164 | 128 | .562 | 2610.2 | 31 | 2.2 |
| Lg | KERSHAW,Clayton | HTA, HUM, SYR | 2008 | 2021 | 14 | 390 | 387 | 82 | 211 | 102 | .674 | 2787.2 | 28 | 2.0 |
| Lg | SABATHIA,C.C. | ARC, BE | 2005 | 2018 | 14 | 406 | 401 | 61 | 159 | 150 | .515 | 2708.1 | 26 | 1.9 |
| Lg | HAREN,Dan | ARC, MBS | 2005 | 2015 | 11 | 388 | 368 | 66 | 146 | 140 | .510 | 2450.1 | 24 | 2.2 |
| Lg | GONZALEZ,Gio | COB, SYR | 2009 | 2019 | 11 | 356 | 261 | 34 | 119 | 98 | .548 | 1885.0 | 22 | 2.0 |
| Lg | VERLANDER,Justin | NAP | 2006 | 2019 | 14 | 415 | 389 | 66 | 207 | 114 | .645 | 2735.1 | 20 | 1.4 |
| Lg | SCHERZER,Max | OMR, SES | 2008 | 2021 | 14 | 391 | 374 | 63 | 181 | 115 | .611 | 2602.0 | 19 | 1.4 |
| Lg | LEE,Cliff | COB, CRC, HOO, LS | 2005 | 2014 | 10 | 284 | 261 | 47 | 137 | 71 | .659 | 1911.1 | 19 | 1.9 |
| Lg | HUDSON,Tim | BAL, GBD, LS | 2005 | 2015 | 11 | 300 | 270 | 39 | 136 | 84 | .618 | 1885.2 | 18 | 1.6 |
| Lg | LYNN,Lance | CRS, HOO, WAS | 2011 | 2021 | 10 | 292 | 275 | 30 | 133 | 79 | .627 | 1854.0 | 18 | 1.8 |
| Lg | SHIELDS,James | AAE, LS, POT | 2006 | 2017 | 11 | 292 | 282 | 53 | 134 | 93 | .590 | 2022.1 | 17 | 1.5 |
| Lg | HALLADAY,Roy | MEN, SAT | 2005 | 2012 | 8 | 241 | 237 | 53 | 126 | 72 | .636 | 1712.2 | 16 | 2.0 |
| Lg | CUETO,Johnny | HOO, MEN, SAT, WAS | 2008 | 2021 | 14 | 274 | 265 | 36 | 122 | 85 | .589 | 1765.1 | 16 | 1.1 |
| Lg | HAMELS,Cole | HOO, LAA, SES | 2006 | 2019 | 14 | 402 | 389 | 23 | 184 | 97 | .655 | 2557.2 | 15 | 1.1 |
| Lg | LESTER,Jon | HOO, MEN, NAP, SAT | 2006 | 2021 | 16 | 395 | 342 | 41 | 167 | 128 | .566 | 2430.0 | 15 | 0.9 |
| Lg | WEAVER,Jered | CSK, HOO, NAP | 2006 | 2016 | 11 | 319 | 295 | 33 | 146 | 91 | .616 | 1995.2 | 15 | 1.4 |
| Lg | ARROYO,Bronson | ABB, BA, HCS | 2005 | 2013 | 8 | 258 | 257 | 45 | 90 | 111 | .448 | 1727.2 | 15 | 1.9 |
| Lg | OSWALT,Roy | HOO, LS | 2005 | 2011 | 7 | 217 | 212 | 38 | 117 | 62 | .654 | 1515.0 | 14 | 2.0 |
| Lg | KEUCHEL,Dallas | ARC, BEG | 2013 | 2021 | 9 | 239 | 236 | 28 | 90 | 94 | .489 | 1509.0 | 14 | 1.6 |
| Lg | DICKEY,R.A. | BE, HOO, HUM, LS, WWC | 2008 | 2017 | 7 | 195 | 187 | 24 | 64 | 76 | .457 | 1232.0 | 14 | 2.0 |
| Lg | SANTANA,Ervin | BB, NJH, SES, SP6 | 2005 | 2017 | 12 | 321 | 312 | 36 | 113 | 135 | .456 | 2044.0 | 14 | 1.2 |
| Lg | LOHSE,Kyle | AS, BOO, CNH, COB, CRC, CSK | 2005 | 2016 | 12 | 314 | 303 | 41 | 128 | 126 | .504 | 2033.2 | 14 | 1.2 |
| Lg | KURODA,Hiroki | WAS | 2008 | 2014 | 7 | 212 | 212 | 31 | 103 | 61 | .628 | 1451.2 | 14 | 2.0 |
| Lg | NIESE,Jonathon | MMW, NAP, SS | 2008 | 2016 | 9 | 222 | 196 | 22 | 71 | 81 | .467 | 1270.1 | 14 | 1.6 |
| Lg | IWAKUMA,Hisashi | BE, CSK | 2012 | 2016 | 5 | 128 | 128 | 24 | 51 | 43 | .543 | 887.2 | 14 | 2.8 |